NIH Researchers Trace Early Journey of Modulating Cells in the Brain

Key cells in the brain region known as the hippocampus are formed in the base of the brain late in fetal life and undertake a long journey before reaching their final destination in the center of the brain shortly after birth, according to researchers at the National Institutes of Health (NIH).

Interneuron cells in the mouse hippocampus

Memory Enhancement Achieved in Rats

Memories are fragile; initially forming and then retrieving them are both dependent on new protein synthesis in the brain, and both processes are vulnerable to disruption. A number of agents are known that can impair memory and these can certainly be useful — for example, in treating post-traumatic stress disorder (ptsd). Enhancing memory, however, has proven more difficult. Yet as noted in The New York Times last week [1], two different research groups have recently reported enhancing memory in rats [2-3]. Of note is the fact that they did so utilizing independent molecular pathways.

Rat in a maze

Rehabilitation After Stroke: They do it with Mirrors

Recent research by Michielsen and colleagues has demonstrated that “mirror therapy”, which can be given at home, results in significant, albeit modest, improvement in arm, wrist and hand movement abilities of stroke patients [1]. Mirror therapy is where the arm with impaired movement is placed behind a mirror and the unimpaired arm is reflected in the mirror, giving the appearance to the patient that when the unimpaired arm is moved, the impaired arm is also moving.

Mirror therapy for stroke rehabilitation

Building a Brain in a Supercomputer

Mental illness, memory, perception: they’re made of neurons and electric signals. Henry Markram claims these mysteries of the mind can be solved — and soon. He is building a detailed, realistic computer model of the human brain and its one hundred trillion — that’s 100,000,000,000,000 — synapses.

Markram is the director of the Blue Brain Project at Ecole polytechnique federale de Lausanne (EPFL), one of two Swiss Federal Institutes of Technology located in Lausanne, Switzerland. Founded in 2005 by the Brain and Mind Institute at the EPFL, Blue Brain is a supercomputing project that to study the brain’s architectural and functional principles, and reverse engineer it in order to understand brain function and dysfunction. Blue Brain can model components of the mammalian brain in precise cellular detail and simulate neuronal activity in 3D. Soon Blue Brain will be able to simulate a whole rat brain in real time.

Brain Awareness Week: Brain Fitness Book Give Away

Here at Highlight HEALTH, we’re very interested in health and wellness, and the evidence-based preventive steps that can be taken to maintain or preclude disease or injury. This same idea applies to brain health: what preventive measures can be taken to improve or retain mental ability and brainpower?

Cognitive decline as you age appears to be largely due to altered connections among brain cells. Keeping the brain active — reading, writing, working crossword or other puzzles, educational courses, memory exercises — appears to strengthen the brain and may build reserves of brain cells and connections.

Today, it’s common to hear the buzzwords “brain fitness”, “brain training” and/or “neuroplasticity”. There are several products available on the market that can help to maintain and/or rebuild cognitive performance. We reviewed the SharpBrains Guide to Brain Fitness when it was released in 2009. The guide aims to help people make informed decisions about brain health and cognitive fitness, based on the latest scientific research, and to help navigate new products and confusing myths and claims that are part of the emerging brain fitness market.

SharpBrains Guide to Brain Fitness book give away

For Brain Awareness Week, SharpBrains has generously provided 5 copies of The SharpBrains Guide to Brain Fitness for us to give away. Here’s how it works:

Simply leave a comment below and tell us in 2-3 sentences how brain research can impact health and/or healthcare. Together with Alvaro Fernandez at SharpBrains, we’ll select the 5 best answers and send the authors a copy of The SharpBrains Guide to Brain Fitness.

If you need ideas to help you get started, check out past stories on the brain here at Highlight HEALTH.

Steps to brain fitness

An unhealthy lifestyle can lead to diseases like obesity, diabetes and brain-related health problems, all of which increase the risk of stroke, dementia and Alzheimer’s disease. These conditions can be managed and even prevented by a healthy lifestyle. Research shows that brain health is promoted by a healthy lifestyle that includes [1]:

  • Eating a brain-healthy diet
  • Staying mentally active
  • Exercising and keeping fit
  • Staying socially engaged
  • Getting plenty of sleep
  • Managing stress
  • Protecting your head from trauma
  • Controlling risk factors
  • Avoiding unhealthy habits
  • Understanding your genetic risk

The decision to review your current lifestyle and start making changes for brain health is truly an important choice to make. Following the healthy steps listed above will be effective at any age; however, the earlier you start, the better off you will be. Your goal should be to make a brain-healthy lifestyle a normal part of your everyday.

References

  1. Steps to Brain Fitness. Alliance for Aging Research. 2006.