Tyrosine kinases are signaling molecules that are frequently mutated as cells become tumorigenic. One of their responsibilities is regulating a cell’s growth based on the extracellular signals they receive. The presence of extracellular growth factors tells them to induce the cell to grow more rapidly, while a lack of oxygen or nutrients tells them to grow more slowly. When these kinases are mutated they make the cell grow uncontrollably, divorcing growth from the conditions outside the cell. In some cases, this mutation is what makes a cell cancerous.
Archives for February 2011
Biomarker Bulletin: February 7, 2011
February 7, 2011 | by
Biomarker Bulletin is an occasionally recurring update of news focused on biomarkers aggregated at BiomarkerCommons.org. Biomarkers are physical, functional or biochemical indicators of normal physiological or disease processes. The individualization of disease management — personalized medicine — is dependent on developing biomarkers that promote specific clinical domains, including early detection, risk, diagnosis, prognosis and predicted response to therapy.
- Prize4Life Awards $1 Million Prize for Discovery of ALS Biomarker
Prize4Life, a non-profit organization dedicated to accelerating the discovery of a cure for Amyotrophic Lateral Sclerosis (ALS) by offering incentives to drive innovation, today announced that Dr. Seward Rutkove, Chief of the Division of Neuromuscular Disease at Beth Israel Deaconess Medical Center and Associate Professor of Neurology at Harvard Medical School, has received the $1 million dollar Prize4Life award for the discovery of a new ALS biomarker.
- Rosetta Genomics Signs Agreements to Advance Development of Body Fluids-Based Diagnostic Tests
Rosetta Genomics has announced that it has signed two new agreements for the development and validation of microRNA-based diagnostics for various indications related to its Gen 3 products. Rosetta Genomics Gen 3 tests focus on cardiovascular indications, neurodegenerative diseases, women’s health and early detection of certain cancers, and are designed to leverage microRNA biomarkers extracted from body fluids.
- Genomic Health Announces Results of Biomarker Discovery Program Using Next-Generation Sequencing
Last week, Genomic Health, Inc. announced that its scientists had successfully used Illumina next-generation sequencing technology to survey expression of the whole human transcriptome and test hypotheses for biomarker discovery in archived tumor and normal breast tissue samples.
- Spinal Muscular Atrophy Foundation and Rules-Based Medicine Collaborate on SMA Biomarker Panel
The Spinal Muscular Atrophy (SMA) Foundation and Rules-based Medicine (RBM) have reached the first milestone in a program to develop a panel of plasma protein biomarkers for SMA using RBM’s Multi-Analyte Profiling (MAP) technology platform.
- Computable Genomix Secures Investment for the Development of Genetic Biomarker Tests
Memphis-based Computable Genomix announced this week that it has secured an investment from venture capital firm Innova Memphis to pilot a novel process for developing genetic biomarker tests. Leveraging its next-generation computational discovery capability, the company is developing highly targeted genetic biomarker tests for clinical researchers.
Daily Aspirin May Reduce Cancer Risk
February 2, 2011 | by
It is old news that aspirin is good for your heart. But a recent report published in The Lancet, the premiere medical journal in the United Kingdom, claims that at least 75mg of aspirin every day can also reduce the risk of developing many different types of cancers.
There is already evidence that taking aspirin every day for five years can reduce the risk of colorectal cancer. Moreover, aspirin has been shown to reduce the incidence and/or growth rate of a number of cancers in animal models. To determine if aspirin can reduce the risk of other cancers in humans, Peter Rothwell and colleagues at the University of Oxford undertook a meta-analysis of eight randomized trials originally performed to study aspirin’s role in preventing vascular events. This study was independent of any commercial interests.
