Archives for February 2010

Alzheimer’s Disease May Protect Against Cancer and Vice Versa

ResearchBlogging.org

As we get older, and care for our parents as they get older, the most feared age-related conditions we face are arguably Alzheimer’s disease and cancer. But researchers at Washington University have just shown that at least we don’t have to fear both of them at the same time; they recently published a paper in the medical journal of the American Academy of Neurology demonstrating that people with Alzheimer’s disease have a significantly reduced risk of being hospitalized for cancer [1].

Feared age-related conditions

This potential link between these two diseases had been noted for some time, but in this study researchers devoted considerable effort to overcoming the limitations in their previous work. Firstly, they used a population-based sample of 3,020 people older than 65, so their results were not limited to a particular geographic area or socio-economic segment of society. Secondly, they used hospital records rather than informant reports to quantify cancer diagnoses. This controlled for the risk that people with Alzheimer’s disease may be less likely to report their cancers than those without. And lastly, to ensure that they were not seeing less cancer in Alzheimer’s patients because physicians were less likely to look for cancer in people with dementia, or because people with dementia simply die earlier than those without it and thereby avoid cancer, they also looked at cancer risk among people with vascular dementia. Vascular dementia is not neurodegenerative in origin; rather, it results from brain damage due to vascular pathology.

Panel Calls for Reducing Colorectal Cancer Deaths by Striking Down Barriers to Screening

Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Despite evidence and guidelines supporting the value of screening for this disease, rates of screening for colorectal cancer are consistently lower than those for other types of cancer, particularly breast and cervical. Although the screening rates in the target population of adults over age 50, have increased from 20-30 percent in 1997 to nearly 55 percent in 2008 – the rates are still too low. An NIH state-of-the-science panel was convened this week to identify ways to further increase the use and quality of colorectal cancer screening in the United States.

“We recognize that some may find colorectal cancer screening tests to be unpleasant and time-consuming. However, we also know that recommended screening strategies reduce colorectal cancer deaths,” said Dr. Donald Steinwachs, panel chair, and professor and director of the Health Services Research and Development Center at the Johns Hopkins University. “We need to find ways to encourage more people to get these important tests.”

The panel found that the most important factors associated with being screened are having insurance coverage and access to a regular health care provider. Their recommendations highlighted the need to remove out-of-pocket costs for screening tests.

Four New Members Appointed to National Neurological Disorders and Stroke Advisory Council

The National Institute of Neurological Disorders and Stroke (NINDS) announced that four new members have joined its National Advisory Neurological Disorders and Stroke Council. The council serves as the principal advisory body to NINDS regarding the Institute’s research program planning and priorities.

“I am delighted to welcome these distinguished new appointees to the advisory council,” said NINDS Director Story Landis, Ph.D. “They include a world-renowned stroke investigator and leader in thrombolytic therapy, a specialist in pediatric neurology and neonatal brain disorders, a neurologist and director of multi-disciplinary research in evidence-based treatment, and a long-time advocate for neurological research who helps families affected by serious diseases.”

NIA Funds Roybal Centers for Translational Research in Aging

The National Institute on Aging (NIA), part of the National Institutes of Health, today announced that it has renewed funding for nine Edward R. Roybal Centers for Research on Applied Gerontology and designated four new centers. The goal of the centers is to move promising social and behavioral research findings out of the laboratory and into programs and practices that will improve the lives of older people and help society adapt to an aging population. The centers focus on a range of projects, including maintaining mobility and physical function, enhancing driving performance, understanding financial and medical decision making, and sharpening cognitive function.

NIH Scientists Identify Maternal and Fetal Genes That Increase Preterm Birth Risk

Researchers at the National Institutes of Health have identified DNA variants in mothers and fetuses that appear to increase the risk for preterm labor and delivery. The DNA variants were in genes involved in the regulation of inflammation and of the extracellular matrix, the mesh-like material that holds cells within tissues.

“A substantial body of scientific evidence indicates that inflammatory hormones may play a significant role in the labor process,” said Alan E. Guttmacher, M.D., acting director of the NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). “The current findings add evidence that individual genetic variation in that response may account for why preterm labor occurs in some pregnancies and not in others.”