Discover the Science of Health
We are all familiar with the negative consequences of getting too little sleep, but they may be more serious than just feeling a bit groggy. A new study published in the journal Science Translational Medicine has shown that sleep restriction, along with a disruption of one’s internal body clock, can raise the risk of obesity and type 2 diabetes [1]. This could explain the increased rates of these conditions in shift workers and others who work at night.
Statins, including Pfizer Inc.’s Lipitor, are among the most prescribed drug in the world, and are currently routinely taken by millions of Americans. They are indicated for people with high blood pressure and/or high cholesterol, and have been shown to significantly reduce the risk of heart disease, heart attack, and stroke in this population. Yet the FDA has just issued new warnings concerning potential side effects: elevated blood sugar, which is a risk factor for developing type 2 diabetes, and cognitive impairment such as memory loss. The warnings will not be affixed to the outside of the bottle, but will be included in the package insert that comes with all prescription medications.
Low levels of physical activity — like the 5,000 steps per day that Americans typically achieve, which is only about half of the recommended amount — have been implicated in the development of insulin resistance and its progression to full blown type 2 diabetes. However, the studies that suggested this connection were performed under laboratory conditions; they did not use people eating real meals, and they did not assess glycemic variability, so the direct impact of physical activity on glycemic control is not completely clear.
Elevated postprandial glucose (PPG) often precedes the development of type 2 diabetes, and is a risk factor for adverse cardiovascular events, independently of diabetes status. Thus, Dr. Catherine Mikus and her colleagues at the University of Missouri set out to precisely define the impact of reducing physical activity on PPG and glycemic variability in healthy, active volunteers as they went about their daily lives. The results of their study were recently published in the journal Medicine and Science in Sports and Exercise [1].
Fat has a bad reputation, both in food and on the body. It’s certainly true that the U.S. has a problem with body fat; according to the U.S. Centers for Disease Control and Prevention (CDC), about two-thirds of adults in the U.S. are overweight, and fully one-third of adults fall into the more serious “obese” category [1]. Still, appropriate amounts of body fat serve valuable roles. These include helping to maintain the immune system and nervous system, protecting body organs and padding areas where the skeleton would otherwise put pressure directly on the skin (such as the soles of the feet).
Too much body fat, however, is associated with a number of negative health effects, including increased risk of heart disease, type 2 diabetes, arthritis, and apnea.
To combat the obesity epidemic, the National Institutes of Health is encouraging diverse scientific investigations through a new Strategic Plan for NIH Obesity Research.
More than one-third of adults in the United States and nearly 17 percent of the nation’s children are now obese, which increases a person’s chance of developing many health problems, including type 2 diabetes, heart disease, high blood pressure, fatty liver disease, and some cancers. Although American obesity rates leveled off in 2007, in 2008, obesity-related medical costs were an estimated $147 billion. Government, nonprofit and community groups, businesses, health care professionals, schools, families, and individuals are taking action to address this public health problem — and research can provide the foundation for these efforts.
