Microneedle Biosensors for Real-time Monitoring Of Body Chemistry

Scientists from North Carolina State University, Sandia National Laboratories, and the University of California, San Diego have developed new technology that enables doctors to detect real-time chemical changes in the body and to do so continuously for an extended period of time.

Scanning electron micrograph of a microneedle

Microneedles are very small needles in which at least one dimension –- such as length –- is less than one millimeter. Existing technology depends on taking samples and testing them; microneedle biosensors instead allow for continuous monitoring in real time.

Dr. Roger Narayan, professor in the joint biomedical engineering department of NC State’s College of Engineering and the University of North Carolina at Chapel Hill, explains:

We’ve loaded the hollow channels within microneedles with electrochemical sensors that can be used to detect specific molecules or pH levels. The idea is that customized microneedle sensor arrays could be developed and incorporated into wearable devices, such as something like a wristwatch, to help answer specific medical or research questions. For example, it could monitor glucose levels in a diabetic patient

The sensors are currently designed to detect glucose, pH levels and lactate. The research was recently published online in the journal Talanta.

Study: Multiplexed Microneedle-based Biosensor Array for Characterization of Metabolic Acidosis

Source: North Carolina State University News

Blueberry Extracts Improve Insulin Sensitivity in Obese Adults

In the United States, 23.6 million children and adults — 7.8% of the population — have diabetes and one-third of U.S. adults are obese [1-2]. Obesity is associated with an increased risk of developing type 2 diabetes as well as insulin resistance, a condition that precedes the development of type 2 diabetes. New research published in the Journal of Nutrition now suggests that blueberries can help improve insulin sensitivity in obese, non-diabetic and insulin-resistant people [3].

Gene Genie #32 – Googling the Genie

Welcome to the 32nd edition of Gene Genie, a blog carnival devoted to genes and genetic conditions. This edition includes some excellent articles on genes and gene-related diseases, genetics, genomics and personalized genetics.

Google Health launched publicly this week and to recognize the event, the last section of the carnival is devoted to articles specifically about the service. Google, financial backer of 23andMe, also funds the Personal Genome Project, which plans to unlock the secrets of common diseases by decoding the DNA of 100,000 people in the world’s biggest gene sequencing project [1]. With the vast number of genetic data points collected for each genome sequenced, a digital system for the movement and storage of personal health information is critical for the widespread use of individualized healthcare. Google’s entrance into the online personal health records market may thus help to accelerate the era of personalized medicine.

With these thoughts in mind, let’s get to this month’s edition of the Genie.