Being physically active is vital to maintaining health and independence as we age, and a new federal campaign for people 50 and older will help them to get active and keep going. Introduced today by the National Institutes of Health (NIH), the Go4Life campaign encourages sedentary older adults to reap health benefits by making physical activity part of their daily lives. Only 25 percent of people aged 65-74 say they engage in regular physical activity.

For over a decade, chondroitin and glucosamine have been recommended in guidelines, prescribed by general practitioners and rheumatologists, and used by patients as over-the-counter medications to modify the clinical and radiological course of arthritis. Nevertheless, a recent meta-analysis in the British Journal of Medicine (BMJ) measuring pain intensity and joint inflammation in over 3,800 patients concludes that chondroitin, glucosamine and their combination do not reduce joint pain or have an impact on narrowing of joint space [1].

Cartilage is an elastic, fibrous connective tissue found in many areas of the human body, including the joints between bones, the elbow, the knee and the ankle. Glucosamine and chondroitin are key structural components in cartilage and are frequently prescribed to reduce joint pain and slow the progression of the disease. It has been thought that oral administration of these compounds compensates for the loss of cartilage in damaged joints. Glucosamine and chondroitin are partially absorbed in the intestine and several studies suggest that at least some of what was ingested can reach the joints. Nevertheless, the recent study, not a clinical trial itself, but a study of studies (i.e. a meta-analysis), compared glucosamine hydrochloride, glucosamine sulphate, and/or chondroitin with placebos and found that none reduced pain intensity or changed the width of joint space (i.e. reduction of inflammation) [1].

Scientists at Stanford and Harvard Universities collaborated to assess the clinical usefulness of analyzing a patient’s full genome for disease risks and unusual drug responses. The work brings closer to reality the concept that whole-genome sequencing might one day play a clinical role.

The analysis, which was supported by the National Institutes of Health (NIH), appears in the May 1, 2010 issue of Lancet.

The authors evaluated the entire genome of a 40-year old man and compared it to several databases of disease-related gene variants. They also factored in the patient’s medical and family history and statistical disease risks. As part of the work, the researchers provided the patient with genetic counseling and clinical tests relevant to his family history.

The genome analysis revealed variants associated with diseases in the man’s family (osteoarthritis, vascular disease and early sudden death). It also uncovered variants linked to conditions not in his family (iron overload and thyroid and parathyroid diseases). Some variants suggested that he might have unusual responses to certain heart medications, which is meaningful in light of his risk for cardiovascular disorders.

Health Highlights is a biweekly summary of particularly interesting articles from credible sources of health and medical information that we follow & read. For a complete list of recommeded sources, see our links page.

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  PLoS Currents is a new and experimental website for the rapid communication of research results and ideas. The first research theme: influenza.

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The Washington Post published a story late last week about obesity in the United States. The story discussed the results of a new study by the Centers for Disease Control and Prevention (CDC). Here’s the article’s opening statement:

The obesity epidemic that has been spreading for more than a quarter-century in the United States has leveled off among women and may have hit a plateau for men …

I was surprised that they use the term “spreading”, since the article fails to mention any of the recent research pertaining to the spread of obesity through social networks.