Bipolar Disorder, also known as manic–depressive disorder, is a condition characterized by alternating states of elevated energy, cognition and mood, with periods of irritable mood and depression. The extreme mood swings experienced by patients with bipolar disorder have been strongly associated with disruptions in circadian rhythms — the 24-hour cycle of biological processes that govern our day and night activity.

Lithium is one of the most common treatments for bipolar disorder. However, little research has been done to find out if and how lithium impacts the brain and peripheral body clockwork. A new study published in the open access journal PLoS ONE reveals a novel link between lithium, bipolar disorder and circadian rhythms [1].