Pharmacogenetic Algorithm Accurately Predicts Warfarin Dosing

This article was written by Noelle K. LoConte, M.D.

Warfarin (brand name Coumadin) is one of the most commonly used anticoagulants (meaning a medication that thins the blood). It is used in a variety of medical situations, including atrial fibrillation, blood clots and when there is an increased risk of blood clotting due to genetic predisposition. When a patient is on warfarin, they need frequent blood draws to measure blood thinness and frequent dose adjustments until they have reached a stable level of blood thinning.


Warfarin Dosing Accuracy and Genomic Medicine: A Helix Health CliniCast

Warfarin, also known under the brand names of Coumadin, Jantoven, Marevan and Waran, is an oral anticoagulant used worldwide for the treatment and prevention of thromboembolic disease. However, warfarin therapy can be difficult to manage because there is a wide variability in patient response and the drug has a narrow therapeutic index. Taking too small a dose can lead to a blood clot while too much can cause life-threatening bleeding.