Vitamin C

Vitamin C is a water-soluble vitamin that is used in many tissues throughout the body. The adrenal gland contains the highest concentration of vitamin C, and the vitamin plays a crucial role in both the adrenal cortex and adrenal medulla [1]. Humans are one of the few species that cannot manufacture the vitamin in the body and must depend on diet or nutritional supplementation as a source of vitamin C. The best sources of vitamin C are fresh fruit (especially in the citrus family, including oranges, lemons, limes and tangerines), strawberries, cantaloupe and currants. Green leafy vegetables, including Brussel sprouts, collard greens, lettuce, cabbage, peas and asparagus, are also good sources.

Dichloroacetate Not Ready for Therapeutic Use

Dichloroacetate has been in the headlines recently, reported to be a cheap, effective cancer cure. The article was published in both print and on the website, and ran with the headline “Cheap, safe drug kills most cancers”, implying incorrectly that it can kill tumor cells in humans.

Researchers at the University of Alberta in Edmonton, Canada, recently reported that they found a cheap and easy drug to produce that is able to cause tumor regression in lung, breast and brain tumor cells grown in culture and lung tumors grown in immunocompromised rats. The drug, Dichloroacetate (DCA), targets mitochondria (meaning an organelle in the cell that produces energy) and induces apoptosis (meaning cell death), decreases proliferation and selectively inhibits cancer cell growth. It did not have any effects on normal, non-cancerous tissue. The findings were published in the January edition of the journal Cancer Cell.

Cancer cells don’t use mitochondria for energy, instead using glycolysis (meaning the initial process of most of carbohydrate metabolism), which is less effective and more wasteful. Researchers have long believed this occurred because mitochondria in cancer cells were damaged. However, this new data suggests that the mitochondria in cancer cells are dormant and DCA reactivates them.

Cancer Prevention

As much as 70% of all cancers are preventable through diet and lifestyle [1]. Cancer is the leading cause of death in the U.S. for people between the ages of 45 and 74, taking more than 550,000 lives a year. The Center for Disease Control (CDC) estimates that 20% of all cancer cases are related to obesity [2]. Highlight HEALTH is taking this opportunity to provide information about choosing healthy lifestyle alternatives to reduce your risks for developing cancer.

Decrease in US Cancer Deaths

In 2003, cancer deaths in the United States decreased by 369 deaths compared to 2002, the first drop seen since 1930. In 2004, the decrease in cancer deaths was eight times greater – 3,014 deaths – than in 2003, according to a report published in the latest issue of the American Cancer Society (ACS) journal CA: A Cancer Journal for Clinicians [1].

Experts are attributing the decreases to declines in smoking, earlier detection and more effective treatment of tumors. The three most common cancers — breast cancer, prostate cancer and colorectal cancer – show a decrease in death rates, with the largest change from colorectal cancer. Experts attribute much of the credit for the reduction in colorectal cancer to screening exams and the early detection of polyps that can be removed before they become cancerous.

Merck Focuses on Traditional Chinese Medicine for Cancer Drugs

Merck recently announced that it will collaborate with Hong Kong-based Chi-Med, a pharmaceutical firm that focuses on researching, developing, manufacturing and selling pharmaceuticals, health supplements and other consumer health and personal care products derived from Traditional Chinese Medicine and botanical ingredients, to develop new cancer drugs.