Exercise Intensity, Not Quantity Reduces Risk of Death from Heart Disease

September 7, 2011 | by

New research suggests that the intensity of exercise might be more important than the quantity in helping to prevent death from heart disease and other causes.

In a study presented last week at the European Society of Cardiology Congress 2011, scientists described new research that examined the relationship between exercise duration, exercise intensity, and total risk of death [1]. Lead researcher Peter Schnohr of Copenhagen, Denmark explained that both male and female cyclists had a decreased total risk of death if they cycled vigorously (by their own perception), but that cycling duration didn’t show a similar protective effect.

Cycling vigorously

Genetic Link Predisposes to Mesothelioma

August 29, 2011 | by

An investigation led by scientists at the University of Hawaii Cancer Center, Honolulu, and Fox Chase Cancer Center, Philadelphia has identified germline mutations in the BAP1 gene that predispose individuals to malignant mesothelioma. The research, published online yesterday in Nature Genetics, describes two U.S. families with a high incidence of mesothelioma, as well as other cancers, associated with mutations of the gene BAP1 [1].

Mesothelioma

Scientists have discovered that individuals who carry a mutation in a gene called BRCA1-associated protein 1 (BAP1) are susceptible to developing two forms of cancer — mesothelioma and melanoma of the eye. When these individuals are exposed to asbestos or similar mineral fibers, their risk of developing mesothelioma, an aggressive cancer of the lining of the chest and abdomen, may be markedly increased.

Repurposing Existing Medicines for New Indications

August 26, 2011 | by

Researchers have developed an innovative way to predict new uses for existing medicines. Using computers and genomic information, scientists at Stanford University in Palo Alto, California, have established a method to identify FDA-approved drugs that may work against diseases they weren’t originally designed to combat. New research published in two articles in the August 17th online issue of Science Translational Medicine highlights two such repurposed drugs that may be used to treat inflammatory bowel disease and lung cancer [1-2].

Repurposing drugs

Herbal Products Missing Key Information Required for Safe Use

August 9, 2011 | by

Between 1996 and 2007, use of herbal supplements in the U.S. rose by a staggering 83% [1]. Many people use herbal medicines mistakenly believing them to be safe simply because they are ‘natural’. However, just like conventional drugs, herbal medicines alter normal body physiology. And despite their wholesome image, many herbal products have adverse effects and may have dangerous interactions with other drugs and dietary supplements. New research published in BioMed Central’s open access journal BMC Medicine reveals that most over-the-counter herbal products do not contain any of the key information required for safe use [2].

Herbal medicines

MIA is a Potential Biomarker for NF1 Tumor Load

July 14, 2011 | by

Neurofibromatosis type 1 is a genetic condition that can cause tumors to form on nerves under the skin. Since these tumors can become malignant, it is important to monitor their growth closely and detect signs of malignant transformation as early as possible. However, the only way to currently detect them is with an MRI scan. New research published in BioMed Central’s open access journal BMC Medicine shows that a simple blood test for the protein melanoma-inhibitory activity (MIA) may be used to indicate the presence of neurofibromas even if they cannot be seen [1].

Blood test