New Strategic NIH Plan to Fight Diabetes

A new strategic plan to guide diabetes-related research over the next decade was announced recently by the National Institutes of Health. The plan, developed by a federal work group led by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), identifies research opportunities with the greatest potential to benefit the millions of Americans who are living with or at risk for diabetes and its complications.

Rehabilitation Study Looks at Getting Stroke Patients Back on Their Feet

In the largest stroke rehabilitation study ever conducted in the United States, stroke patients who had physical therapy at home improved their ability to walk just as well as those who were treated in a training program that requires the use of a body-weight supported treadmill device followed by walking practice.

The study, funded by the National Institutes of Health, also found that patients continued to improve up to one year after stroke, defying conventional wisdom that recovery occurs early and tops out at six months. In fact, even patients who started rehabilitation as late as six months after stroke were able to improve their walking.

The results of the study were announced last month at the American Stroke Association’s International Stroke Conference 2011 in Los Angeles. NIH’s National Institute of Neurological Disorders and Stroke (NINDS) provided primary funding for the study.

Exercise on a treadmill

NHGRI Vision to Move Genomic Medicine from Base Pairs to Bedside

A new strategic plan from an arm of the National Institutes of Health envisions scientists being able to identify genetic bases of most single-gene disorders and gaining new insights into multi-gene disorders in the next decade. This should lead to more accurate diagnoses, new drug targets and the development of practical treatments for many who today lack therapeutic options, according to the plan from the National Human Genome Research Institute (NHGRI).

Base pairs to bedside

Growth Factor Enhances Memory, Prevents Forgetting in Rats

A naturally occurring growth factor significantly boosted retention and prevented forgetting of a fear memory when injected into rats’ memory circuitry during time-limited windows when memories become fragile and changeable. In a study funded by the National Institutes of Health (NIH), animals treated with insulin-like growth factor (IGF2) excelled at remembering to avoid a location where they had previously experienced a mild shock [1].

Nerve Stimulation Stops the Ring of Tinnitus in Rats

NIH-funded researchers were able to eliminate tinnitus in a group of rats by stimulating a nerve in the neck while simultaneously playing a variety of sound tones over an extended period of time, says a study published today in the advance online publication of the journal Nature [1]. The hallmark of tinnitus is often a persistent ringing in the ears that is annoying for some, debilitating for others, and currently incurable. Similar to pressing a reset button in the brain, this new therapy was found to help retrain the part of the brain that interprets sound so that errant neurons reverted back to their original state and the ringing disappeared. The research was conducted by scientists from the University of Texas at Dallas and MicroTransponder Inc., in Dallas.