Archives for August 2009

Metabolic Discoveries Hidden In Our Genomes

August 25, 2009 | by

This article was written by Allison Bland.

A recent study in the Proceedings of the National Academy of Sciences (PNAS) hints at a future where a daily multivitamin could be replaced with a personalized vitamin that would work with the unique genetic makeup of an individual’s genome [1]. Studies have repeatedly cast doubt on the effects of vitamins for the prevention of cancer and other diseases, and doctors and scientists are mixed in their recommendations for taking these supplements. A doctor may prescribe vitamins to cure metabolic diseases, but the enzymes that do this metabolic work in our bodies vary from person to person because of genetic mutations that cause them to function slightly differently.

Digital Pathology and Visuvi Visual Search

August 13, 2009 | by

At the 2009 JavaOne Conference in June, Visuvi Inc., a Redwood City, California-based company developing visual search solutions, announced a Java-based visual search technology that integrates a JavaFX front-end with PathXchange, a Web 2.0 pathology portal. The Visuvi Java application enables medical professionals to take a digital biopsy image of 50,000 x 60,000 pixels (that’s 3000 mega pixels) and search medical images in leading databases for similarities.

The power of this technology is that the medical images in the databases have corresponding case information. Thus, images that are found to be similar also provide information on patient diagnosis, treatments, outcomes, etc. This is particulary useful in oncology since, in more cases than you’d expect, pathologists disagree on whether a particular image shows cancer or not [1-3]. By comparing pathology images, the technology greatly accelerates the review process and allows a diagnosis to be more objective than what is currently done.

Check out their demo at the conference in the video below. James Gosling (the inventor of Java) was clearly impressed with the significance of the technology. Chris Boone, CEO and president of Visuvi, and Florian Brody, VP Marketing, highlighted and captured a section of an actual prostate cancer biopsy image and searched 90,000 images in 0.3 seconds to find related patient cases.

PathXchange is a not-for-profit professional networking portal for the global pathology community. PathXchange brings the field of pathology into the digital age with Web 2.0 features designed to promote exchange of pathological cases, knowledge and information, combining the elements of a case gallery, community content contribution and professional networking.

References

  1. Farmer et al. Discordance in the histopathologic diagnosis of melanoma and melanocytic nevi between expert pathologists. Hum Pathol. 1996 Jun;27(6):528-31.
    View abstract
  2. Lettieri et al. Discordance between general and pulmonary pathologists in the diagnosis of interstitial lung disease. Respir Med. 2005 Nov;99(11):1425-30. Epub 2005 Apr 21.
    View abstract
  3. Lodha et al. Discordance in the histopathologic diagnosis of difficult melanocytic neoplasms in the clinical setting. J Cutan Pathol. 2008 Apr;35(4):349-52.
    View abstract

NIH to Hold Conference on Family History

August 11, 2009 | by

People who have family members with certain diseases are more likely to develop those diseases themselves. Indeed, many common disorders, including cancer, diabetes, heart disease and stroke, have genetic, environmental, behavioral and lifestyle causes that are shared between family members and together contribute to an individual’s risk for developing disease.

A family health history is a written or graphic record of these factors and includes information on diseases and health conditions of biological relatives, the age at diagnosis, and the age and cause of death of deceased family members. Family health history information collected from patients has long been used by healthcare providers in the U.S. as a risk assessment tool, and has gained renewed attention with efforts in personalized medicine. Americans recognize the importance of family history to health. A recent survey found an overwhelming 96% of respondents believe their family history is important for their own health; nevertheless, only 30% have actively collected health information from their relatives to develop a family history [1].

Despite the widespread and longstanding use of family health history, important questions regarding the effectiveness of family history information for disease prediction and improvement of health outcomes remain.

Health Highlights – August 7th, 2009

August 7, 2009 | by

Health Highlights is a biweekly summary of particularly interesting articles from credible sources of health and medical information that we follow & read. For a complete list of recommeded sources, see our links page.

Health Highlights

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The Spectrum Health Value Study: Insured vs. Uninsured

August 6, 2009 | by

In May, we wrote about the Spectrum Health Value Study, an ongoing national online survey where Americans are asked what they value when it comes to healthcare products and services. The survey evaluates 27 programs, products and services categories used by the U.S. government for measuring economic activity in various sectors of the economy. Every three months, Spectrum, a public relations and public affairs firm based in Washington DC, interviews 1,000 people and asks them to identify from the 27 healthcare products, programs and services those ever used and how satisfied they were with each. The ongoing study can be used to identify the relative value Americans place in healthcare programs, products and services, and how the value changes over time.

spectrum-health-value-study

Insured and uninsured

The most recent Spectrum Health Value Study data was used to compare answers from insured and uninsured respondents. As Congress recesses for the month of August to talk with their constituents about the current healthcare legislation under consideration in the U.S. House and Senate, these data offer a glimpse into what insured and uninsured Americans value in healthcare.