Archives for February 2007

Vitamin C

Vitamin C is a water-soluble vitamin that is used in many tissues throughout the body. The adrenal gland contains the highest concentration of vitamin C, and the vitamin plays a crucial role in both the adrenal cortex and adrenal medulla [1]. Humans are one of the few species that cannot manufacture the vitamin in the body and must depend on diet or nutritional supplementation as a source of vitamin C. The best sources of vitamin C are fresh fruit (especially in the citrus family, including oranges, lemons, limes and tangerines), strawberries, cantaloupe and currants. Green leafy vegetables, including Brussel sprouts, collard greens, lettuce, cabbage, peas and asparagus, are also good sources.

Caffeine May Prevent Heart Disease in the Elderly

Habitual intake of caffeinated beverages provides protection against the risk of heart disease mortality among the elderly. The study, published in this months issue of The American Journal of Clinical Nutrition, found that participants 65 years of age or older with higher caffeinated beverage intake exhibited lower relative risk of cardiovascular disease and heart disease mortality than did participants with lower caffeinated beverage intake [1].

Peanut Butter Recalled Due to Salmonella Outbreak

Nearly 300 people in 39 states have fallen ill since August 2006, linked to a Salmonella outbreak from peanut butter. It is believed to be the first Salmonella outbreak in U.S. history associated with peanut butter. Just two or fewer cases have been reported each day since August, Centers for Disease Control and Prevention (CDC) officials said, and it was only in the past few days that investigators were able to focus in on the particular food responsible. The highest number of Salmonella cases reported were in New York, Pennsylvania, Virginia, Tennessee and Missouri. According to the CDC, about 20% of the 288 infected people were hospitalized but no one has died.

The Best Way to Stay Healthy and Avoid Getting Sick

The best way to stay healthy and avoid getting sick is to wash your hands. Some of the most recent scientific evidence comes from a study of hospital-acquired methicillin-resistant Staphylococcus aureus infection. Methicillin-resistant Staphylococcus aureus (MRSA or “staph”) is a bacteria that can enter the body through breaks in the skin and cause severe infections and even death, especially in people who are already sick. MRSA represents a major control problem in hospitals as it has developed a resistance to all penicillins, including methicillin and other narrow-spectrum beta-lactamase-resistant penicillin antibiotics [1]. Researchers concluded at the end of the study that hospitals could greatly limit the spread of MRSA through the use of increased barrier protection (gloves) by workers and more frequent hand washing [2].

Dichloroacetate Not Ready for Therapeutic Use

Dichloroacetate has been in the headlines recently, reported to be a cheap, effective cancer cure. The article was published in both print and on the website NewScientist.com, and ran with the headline “Cheap, safe drug kills most cancers”, implying incorrectly that it can kill tumor cells in humans.

Researchers at the University of Alberta in Edmonton, Canada, recently reported that they found a cheap and easy drug to produce that is able to cause tumor regression in lung, breast and brain tumor cells grown in culture and lung tumors grown in immunocompromised rats. The drug, Dichloroacetate (DCA), targets mitochondria (meaning an organelle in the cell that produces energy) and induces apoptosis (meaning cell death), decreases proliferation and selectively inhibits cancer cell growth. It did not have any effects on normal, non-cancerous tissue. The findings were published in the January edition of the journal Cancer Cell.

Cancer cells don’t use mitochondria for energy, instead using glycolysis (meaning the initial process of most of carbohydrate metabolism), which is less effective and more wasteful. Researchers have long believed this occurred because mitochondria in cancer cells were damaged. However, this new data suggests that the mitochondria in cancer cells are dormant and DCA reactivates them.