NIDA Researchers Discover a New Mechanism Underlying Cocaine Addiction

NIH Research News

Researchers have identified a key epigenetic mechanism in the brain that helps explain cocaine’s addictiveness, according to research funded by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health.

The study, published in the January issue of the journal Science, shows how cocaine affects an epigenetic process (a process capable of influencing gene expression without changing a gene’s sequence) called histone methylation. These epigenetic changes in the brain’s pleasure circuits, which are also the first impacted by chronic cocaine exposure, likely contribute to an acquired preference for cocaine.

NIDA Director Honored By French Government With Top Science Award for Addiction Research

Dr. Nora D. Volkow, director of the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, has been awarded the International Prize from the French Institute of Health and Medical Research (Inserm) for her pioneering work in brain imaging and addiction science. Dr. Volkow will receive the award at a Dec. 17 ceremony at the College of France learning center in Paris.