Discover the Science of Health
High-fructose corn syrup, common in processed foods, is more likely than table sugar to increase the rate and amount of weight gain, according to a study in Pharmacology, Biochemistry and Behavior [1]. Specifically, consuming high-fructose corn syrup (HFCS) increases the likelihood of gaining abdominal fat, which is particularly dangerous with regard to risk of heart disease.
To combat the obesity epidemic, the National Institutes of Health is encouraging diverse scientific investigations through a new Strategic Plan for NIH Obesity Research.
More than one-third of adults in the United States and nearly 17 percent of the nation’s children are now obese, which increases a person’s chance of developing many health problems, including type 2 diabetes, heart disease, high blood pressure, fatty liver disease, and some cancers. Although American obesity rates leveled off in 2007, in 2008, obesity-related medical costs were an estimated $147 billion. Government, nonprofit and community groups, businesses, health care professionals, schools, families, and individuals are taking action to address this public health problem — and research can provide the foundation for these efforts.
December can be a fun, joyous season. Families everywhere are celebrating Christmas, Hanukkah and Kwanzaa. Each of these winter holidays brings many festivities and lots of yummy, delicious food. The temptation to eat and drink in excess can be hard to overcome.
Although getting your five-a-day is important for promoting good health, overindulging on anything is bad for you. Indeed, overindulgence — consuming more calories than your body requires — is one of the main factors contributing to weight gain. Many of us love sweets during the holidays, but large portions won’t do anything but add surplus calories that get converted into fat.
Consider Santa Claus. One of the benefits of being “good St. Nick” is eating all the holiday cookies left by children around the world on Christmas eve.
Some of the same brain mechanisms that fuel drug addiction in humans accompany the emergence of compulsive eating behaviors and the development of obesity in animals, according to research funded by the National Institute on Drug Abuse (NIDA), a component of the National Institutes of Health.
The study, conducted by researchers at the Scripps Research Institute, was released on March 28th in the online version of Nature Neuroscience and will also appear in the journal’s May 2010 print issue. When investigators gave rats access to varying levels of high-fat foods, they found unrestricted availability alone can trigger addiction-like responses in the brain, leading to compulsive eating behaviors and the onset of obesity.
“Drug addiction and obesity are two of the most challenging health problems in the United States,” said Dr. Nora D. Volkow, director of NIDA. “This research opens the door for us to apply some of the knowledge we have gathered about drug addiction to the study of overeating and obesity.”
Both obesity and drug addiction have been linked to a dysfunction in the brain’s reward system. In both cases overconsumption can trigger a gradual increase in the reward threshold — requiring more and more palatable high fat food or reinforcing drug to satisfy the craving over time.
The National Institutes of Health is launching a $37 million program that will use findings from basic research on human behavior to develop more effective interventions to reduce obesity. The program, Translating Basic Behavioral and Social Science Discoveries into Interventions to Reduce Obesity, will fund interdisciplinary teams of researchers at seven research sites. Investigators will conduct experimental research, formative research to increase understanding of populations being studied, small studies known as proof of concept trials, and pilot and feasibility studies to identify promising new avenues for encouraging behaviors that prevent or treat obesity.
