Spinal Muscular Atrophy Legislation to be Introduced in Congress

July 13, 2007 | by

Spinal muscular atrophy legislation, “The SMA Treatment Acceleration Act”, will soon be introduced in both the U.S House of Representatives and the U.S. Senate.

What is spinal muscular atrophy?

Spinal muscular atrophy (SMA) is an autosomal recessive (meaning the disorder is inherited by receiving one gene from both mother and father) neuromuscluar disorder that affects motor neurons of the spinal cord and brainstem. Motor neurons are responsible for supplying electrical and chemical messages to muscle cells. Without proper input from motor neurons, muscle cells don’t function properly and become much smaller (atrophy), producing symptoms of muscle weakness and affecting the ability to swallow, breath and move limbs.

In Memorandum

May 17, 2007 | by

The medical blogosphere lost two important voices this week. FatDoctor was forced to shut down her blog due to privacy concerns. Flea’s blog mysteriously vanished. Given that he has been blogging about his malpractice trial, it’s likely that his blog also was taken down because of privacy issues. Hopefully, we’ll see his blog reappear when the litigation has finished.

FDA Attempting to Regulate Dietary Supplements

April 26, 2007 | by

A new U.S. Food and Drug Administration (FDA) docket was published on the FDA website last month. The draft guidance, when finalized, will represent the FDA’s current thinking on complementary and alternative medicine (CAM). Docket No. 2006D-0480: Draft Guidance for Industry on Complementary and Alternative Medicine Products and Their Regulation by the Food and Drug Administration [1] discusses when a CAM product is subject to the Federal Food, Drug, and Cosmetic Act (the Act) or the Public Health Service (PHS) Act.

Peanut Butter Recalled Due to Salmonella Outbreak

February 17, 2007 | by

Nearly 300 people in 39 states have fallen ill since August 2006, linked to a Salmonella outbreak from peanut butter. It is believed to be the first Salmonella outbreak in U.S. history associated with peanut butter. Just two or fewer cases have been reported each day since August, Centers for Disease Control and Prevention (CDC) officials said, and it was only in the past few days that investigators were able to focus in on the particular food responsible. The highest number of Salmonella cases reported were in New York, Pennsylvania, Virginia, Tennessee and Missouri. According to the CDC, about 20% of the 288 infected people were hospitalized but no one has died.

Dichloroacetate Not Ready for Therapeutic Use

February 11, 2007 | by

Dichloroacetate has been in the headlines recently, reported to be a cheap, effective cancer cure. The article was published in both print and on the website NewScientist.com, and ran with the headline “Cheap, safe drug kills most cancers”, implying incorrectly that it can kill tumor cells in humans.

Researchers at the University of Alberta in Edmonton, Canada, recently reported that they found a cheap and easy drug to produce that is able to cause tumor regression in lung, breast and brain tumor cells grown in culture and lung tumors grown in immunocompromised rats. The drug, Dichloroacetate (DCA), targets mitochondria (meaning an organelle in the cell that produces energy) and induces apoptosis (meaning cell death), decreases proliferation and selectively inhibits cancer cell growth. It did not have any effects on normal, non-cancerous tissue. The findings were published in the January edition of the journal Cancer Cell.

Cancer cells don’t use mitochondria for energy, instead using glycolysis (meaning the initial process of most of carbohydrate metabolism), which is less effective and more wasteful. Researchers have long believed this occurred because mitochondria in cancer cells were damaged. However, this new data suggests that the mitochondria in cancer cells are dormant and DCA reactivates them.