With all the recent discussion and debate by the presidential candidates regarding healthcare issues, I thought a study published last month in CA: A Cancer Journal for Clinicians was quite timely. The study, titled Association of Insurance with Cancer Care Utilization and Outcomes, presents evidence that lack of adequate health insurance coverage is associated with reduced access to care and poorer outcomes for cancer patients [1]. The article further presents data on the association between health insurance status and screening, stage at diagnosis and survival for breast and colorectal cancer.

Today, the American Cancer Society (ACS) celebrates the Great American Smokeout, an annual event in the U.S. to encourage Americans to quit smoking. According to the U.S. Centers for Disease Control and Prevention (CDC), in 2006 one in five U.S. adults smoked [1]. The Great American Smokeout challenges those people to smoke less or quit smoking for the day. The event also raises awareness of the many effective ways to quit for good.

The ACS has just wrapped up their first ever video contest on YouTube, where they asked people to create videos – one minute or less – to discourage smoking. You can check out the contest winners at the American Cancer Society.

You can also read more about the harmful effects of smoking and tobacco smoke in these articles here at Highlight HEALTH:

• Smoking Duration vs. Intensity and the Impact on Lung Cancer Risk
• Irreversible Gene Expression Changes From Smoking
• Smoking Cessation Timeline: What Happens When You Quit
• Second-hand Smoke Exposure Linked to Psychological Problems in Children

Accept the Great American Smokeout Challenge.
Quit for one day, or quit for good.

References

1. Cigarette smoking among adults–United States, 2006. Centers for Disease Control and Prevention (CDC). MMWR Morb Mortal Wkly Rep. 2007 Nov 9;56(44):1157-61.
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A study published in the journal Cancer Research last month suggests that the principle treatment for advanced prostate cancer may actually encourage prostate cancer cells to metastasize [1]. Researchers at The Johns Hopkins University School of Medicine focused on a gene called Nestin, which encodes an intermediate filament protein. Intermediate filaments are cytoskeletal or scaffolding structures found in cells that, in addition to maintaining cell shape, control a variety of cellular processes including proliferation, migration and survival [2]. Nestin gene expression also distinguishes stem cells from differentiated cells and has been shown to be activated in pediatric brain tumors and rhabdomyosarcomas (cancers that develop from skeletal muscle), central nervous system tumors and gastrointestinal stromal tumors [3-6].

We’ve discussed smoking and health a number of times recently:

• Smoking Cessation Timeline: What Happens When You Quit
• Irreversible Gene Expression Changes From Smoking

One of our readers asked a question I’m sure many have us have wondered about at one time or another:

Which is worse for the development of lung cancer — smoking heavily over a short period of time or smoking fewer cigarettes over many years?

Here’s what the research has to say:

Recent research published in the online open journal BMC Genomics shows that smoking leads to changes in gene expression, some of which are reversible and some of which are permanent. Genes that are irreversibly changed may help to explain why former smokers, even after 10 years of not smoking, are still more susceptible to lung cancer than those who have never smoked.